Joel Z. Nordin

Lipid-ASO therapeutics exhibit differential tissue targeted delivery upon systemic or local CNS administration

This study compares lipid-conjugated ASO delivery in mice, showing differential tissue and CNS targeting based on lipid type and administration route.

Efficient genome editing in the non-human primate brain using programmable extracellular vesicles

This paper demonstrates efficient genome editing in non-human primate brains using engineered extracellular vesicles, achieving therapeutic potential for neurological disorders.

Evaluation of Tetraspanins in Extracellular Vesicle Bioengineering

This study investigates the role of tetraspanins in EV bioengineering by knocking out CD9, CD63, and CD81 in HEK293T cells and shows increased engineered EV production upon reintroduction of tetraspanin-fusion constructs.

Efficient delivery of gene editors using intein-engineered virus-like particles

This paper develops intein-engineered virus-like particles for efficient gene editing delivery, achieving robust gene editing in multiple cell types and organs.

Advanced Peptide Nanoparticles Enable Robust and Efficient delivery of gene editors across cell types

This paper develops hPep-based nanoparticles for efficient delivery of gene editors across multiple cell types, achieving high editing efficiency in human cells.

Histones are exosome membrane proteins regulated by cell stress

This study identifies histones as exosome membrane proteins regulated by cell stress, showing they are secreted via the exosome pathway and lack nuclear post-translational modifications.

Identification of Novel Scaffold Proteins for Improved Endogenous Engineering of Extracellular Vesicles

The paper identifies 24 novel scaffold proteins with conserved EV-sorting abilities, outperforming CD63 in cargo loading and demonstrating improved EV engineering potential.

Profiling of extracellular small RNAs highlights a strong bias towards non-vesicular secretion

The paper shows that most extracellular miRNAs are secreted non-vesicularly, with only <2% associated with EVs, even though EVs can stabilize miRNAs in serum.

Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle

This study engineers extracellular vesicles with IL6ST decoy receptors to inhibit the IL6 trans-signalling pathway, showing efficacy in vitro and in a Duchenne muscular dystrophy mouse model.