Oscar P. B. Wiklander

This paper introduces a customizable bead-based platform for isolating and detecting specific EV populations in plasma, demonstrating sensitivity and the ability to distinguish clinically relevant biomarker expressions.

This study shows that chemical modifications to siRNA and linkers in AOCs can improve potency and tissue targeting while allowing higher payload loading.

This study develops bioengineered extracellular vesicles that neutralize pneumolysin and reduce inflammation in pneumococcal meningitis, improving survival in a mouse model.

This study characterizes gene expression in human growth plates, identifying novel markers and sub-populations of resting zone chondrocytes with features of quiescent stem cells.

This study shows that dynasore, a dynamin inhibitor, has hormetic effects on bone growth, stimulating elongation at low doses and inhibiting growth at high doses.

This study develops an engineered extracellular vesicle platform that improves shRNA loading and delivery efficiency, achieving robust gene silencing in multiple cell types and the mouse brain.

This study shows that systemic inflammation significantly prolongs EV plasma half-life and enhances their accumulation in inflamed organs like the liver and spleen.

This study identifies mitoEV-mediated mitochondrial transfer from astrocytes to neurons as a compromised pathway in early Alzheimer's disease, revealing its role in supporting neuronal energy metabolism.

This study investigates the role of tetraspanins in EV bioengineering by knocking out CD9, CD63, and CD81 in HEK293T cells and shows increased engineered EV production upon reintroduction of tetraspanin-fusion constructs.

This paper develops intein-engineered virus-like particles for efficient gene editing delivery, achieving robust gene editing in multiple cell types and organs.

This paper develops hPep peptide-based nanoparticles for systemic mRNA delivery, showing effective tissue distribution and protein expression in mice and non-human primates.

This study identifies histones as exosome membrane proteins regulated by cell stress, showing they are secreted via the exosome pathway and lack nuclear post-translational modifications.

The paper identifies 24 novel scaffold proteins with conserved EV-sorting abilities, outperforming CD63 in cargo loading and demonstrating improved EV engineering potential.

This study engineers extracellular vesicles with IL6ST decoy receptors to inhibit the IL6 trans-signalling pathway, showing efficacy in vitro and in a Duchenne muscular dystrophy mouse model.