Viral rewiring of APC/C-CDC20 drives Aurora B hyperubiquitination, mitotic regression and polyploidy
Shikha Srivastava, Debkanya Sengupta, Yllza Jasiqi, Vanessa R Povolo, Michael Bauer, Mathieu Hubert, Uta Haselmann, Martin Schneider, Dominic Helm, Urs F. Greber, Vibhu Ranjan Prasad
This study shows that adenovirus E4orf4 interacts with CDC20 to redirect APC/C-CDC20 towards Aurora B, causing hyperubiquitination and mitotic regression, leading to polyploidy.
bioRxiv · Feb 15, 2026 · PreprintCell Biology