Mathieu Hubert

Viral rewiring of APC/C-CDC20 drives Aurora B hyperubiquitination, mitotic regression and polyploidy

This study shows that adenovirus E4orf4 interacts with CDC20 to redirect APC/C-CDC20 towards Aurora B, causing hyperubiquitination and mitotic regression, leading to polyploidy.

Human airway organoids as a high-throughput screening platform for antiviral natural products discovery

This study uses human airway organoids to screen 764 natural plant extracts for antiviral activity against RSV, identifying 45 active compounds with distinct mechanisms.

Generation of apical-out nasal organoids to facilitate viral infection and drug screening

This paper describes a method to generate apical-out nasal organoids from nasal epithelial cells, which can be used for studying viral infections and drug responses.

Potent Neutralization by Antibodies Targeting the Mpox A28 Protein

The paper identifies and characterizes monoclonal antibodies targeting the Mpox A28 protein, showing potent neutralization of Mpox and Vaccinia virus through complement-dependent mechanisms and providing protection in mice.

Poor sensitivity of iPSC-derived neural progenitors and glutamatergic neurons to SARS-CoV-2

This study shows that iPSC-derived neural progenitors and glutamatergic neurons are not permissive to SARS-CoV-2 infection unless ACE2 is overexpressed.

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.