Martin Schneider

This study identifies TRIM11 as a regulator of EWSR1::ATF1 stability in clear cell sarcoma, showing its depletion leads to metabolic rewiring and cell death, with PCK1 as a potential biomarker.

This study shows that the cell-of-origin, not oncogenic pathway activation, determines the desmoplastic immune-excluded tumor microenvironment in KRAS-driven liver cancer.

This study shows that adenovirus E4orf4 interacts with CDC20 to redirect APC/C-CDC20 towards Aurora B, causing hyperubiquitination and mitotic regression, leading to polyploidy.

This study shows that SS18::SSX can drive transcription independently of BAF complex interaction and relies on EP300 for gene activation, suggesting new therapeutic targets for synovial sarcoma.

ProteoBench provides a centralized platform for comparing proteomics data analysis workflows, enabling benchmarking and community collaboration.

This study identifies mRAVE as a mammalian V-ATPase assembly factor that links organelle acidification to function and nutrient signaling.

This study uses T-DARPins to inhibit TBXT in chordoma cells, revealing its regulome and identifying therapeutic vulnerabilities, including sensitivity to JAK2 inhibitors.

The paper identifies 218 C16:0-acylated and 308 C18-lipid-acylated proteins, showing widespread competition for acylation across the proteome.