Cell BiologybioRxivPreprint
Viral rewiring of APC/C-CDC20 drives Aurora B hyperubiquitination, mitotic regression and polyploidy
Shikha Srivastava, Debkanya Sengupta, Yllza Jasiqi…·Vibhu Ranjan Prasad
This study shows that adenovirus E4orf4 interacts with CDC20 to redirect APC/C-CDC20 towards Aurora B, causing hyperubiquitination and mitotic regression, leading to polyploidy.
DOI 10.64898/2026.02.13.705602