Author

K. Wellen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:metabolomics· 1

Frequent Co-Authors

A. D. Amin· 1 shared A. Sahasrabuddhe· 1 shared A. Singh· 1 shared C. Bekeova· 1 shared C. Burant· 1 shared C. Costa· 1 shared C. Thai· 1 shared D. Bartee· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperCancer Biology

A. D. Amin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ATP citrate lyase is an essential player of the metabolic rewiring induced by PTEN loss during T-ALL development.

G. Andrieu, G. Hypolite, E. Balducci, C. Costa, E. Verhoeyen, I. Nemazanyy, G. Panasyuk, K. Wellen, E. Macintyre, V. Asnafi, M. Tesio

This study identifies ATP citrate lyase (ACLY) as a critical metabolic driver in PTEN-deficient T-ALL, showing its essential role in disease progression and therapeutic targeting potential.

bioRxiv · Mar 27, 2023Cancer Biology

Therapeutic targeting of ACLY in T-ALL in vivo

V. da Silva-Diz, A. Singh, M. Aleksandrova, O. Kim, C. Thai, O. Lancho, P. R. Nunes, H. Affronti, X. Su, K. Wellen, D. Herranz

This study identifies ACLY as an overexpressed therapeutic target in T-ALL, showing its antileukemic effects and reciprocal relationship with MYC.

bioRxiv · Mar 27, 2023Cancer Biology

Quantification of lactoyl-CoA (lactyl-CoA) by liquid chromatography mass spectrometry in mammalian cells and tissues

E. L. Varner, S. Trefely, D. Bartee, E. von Krusenstiern, L. Izzo, C. Bekeova, R. S. O'Connor, E. L. Seifert, K. Wellen, J. L. Meier, N. W. Snyder

This paper quantifies lactoyl-CoA in mammalian cells and tissues using LC-HRMS and provides a biosynthetic method for isotopically labeled lactoyl-CoA.

bioRxiv · Mar 15, 2020 · PreprintBiochemistry

Tyrosine phosphorylation of ACLY regulates lipid metabolism and oncogenesis in ALK positive Anaplastic Large Cell Lymphoma

J. Basappa, M. ElAzzouny, D. Rolland, A. Sahasrabuddhe, K. Ma, G. Bazilevsky, S. R. Hwang, V. Basrur, K. Conlon, N. Bailey, J. Frederiksen, S. Schnell, Y. Zhou, D. Cookmeyer, J. Pawlicki, , M. Lim

This study identifies tyrosine phosphorylation of ACLY at Y682 as a regulatory mechanism linked to lipid metabolism and oncogenesis in ALK-positive ALCL.

bioRxiv · Jan 20, 2020 · PreprintCancer Biology