Piezo1 channel agonist mimics high glucose as a stimulator of insulin release
V. Deivasikamani, S. Dhayalan, R. Mughal, A. Visnagri, K. Cuthbertson, J. L. Scragg, T. S. Munsey, H. Viswambharan, R. Foster, A. Sivaprasadarao, M. T. Kearney, D. J. Beech, P. Sukumar
This study shows that Piezo1 agonist Yoda1 stimulates insulin release from beta-cells and pancreatic islets, suggesting Piezo1's role in cell swelling-induced insulin secretion.
bioRxiv · Oct 29, 2018Cell Biology