Author

H. Viswambharan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

D. J. Beech· 3 shared K. Bridge· 2 shared M. T. Kearney· 2 shared P. Sukumar· 2 shared R. Cubbon· 2 shared R. Mughal· 2 shared A. M. N. Walker· 1 shared A. Moron· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCell Biology

D. J. Beech

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Author profile →

3 papers

Recent·Most cited

A small molecule reveals role of insulin receptor-insulin like growth factor-1 receptor heterodimers

K. J. Simmons, C. G. Myers, H. Viswambharan, N. Haywood, K. Bridge, S. J. Turvey, T. Armstrong, L. Lunn, P. J. Meakin, E. Clavane, D. J. Beech, R. Cubbon, S. B. Wheatcroft, M. J. McPhillie, C. W. Fishwick, M. T. Kearney

The paper identifies a small molecule that inhibits insulin receptor-insulin-like growth factor-1 receptor heterodimers, revealing their distinct physiological role in endothelial cells.

bioRxiv · Dec 9, 2021 · PreprintCell Biology

Paracrine role for endothelial IGF-1 receptor in white adipocyte beiging

N. J. Haywood, K. Bridge, C. Luk, N. Warmke, K. Simmons, M. Drozd, A. Moron, S. Straw, J. Scragg, J. Smith, S. Limumpornpetch, C. Ozber, C. Wilkinson, A. Skromna, N. Makava, , M. Kearney

This study shows that reducing endothelial IGF-1R in nutrient excess promotes white adipocyte beiging, increases energy expenditure, and improves insulin sensitivity through paracrine malonic acid release.

bioRxiv · Dec 1, 2021 · PreprintCell Biology

Piezo1 channel agonist mimics high glucose as a stimulator of insulin release

V. Deivasikamani, S. Dhayalan, R. Mughal, A. Visnagri, K. Cuthbertson, J. L. Scragg, T. S. Munsey, H. Viswambharan, R. Foster, A. Sivaprasadarao, M. T. Kearney, D. J. Beech, P. Sukumar

This study shows that Piezo1 agonist Yoda1 stimulates insulin release from beta-cells and pancreatic islets, suggesting Piezo1's role in cell swelling-induced insulin secretion.

bioRxiv · Oct 29, 2018Cell Biology