Oncogene-like addiction to aneuploidy in human cancers
V. Girish, A. A. Lakhani, C. M. Scaduto, S. L. Thompson, L. M. Brown, R. A. Hagenson, E. L. Sausville, B. E. Mendelson, D. A. Lukow, M. L. Yuan, P. K. Kandikuppa, E. C. Stevens, S. N. Lee, B. Salovska, W. Li, , J. M. Sheltzer
This study demonstrates that trisomy of chromosome 1q is essential for malignant growth in cancers and shows that TP53 mutations are mutually exclusive with 1q aneuploidy.
bioRxiv · Jan 9, 2023Cancer Biology