Author

M. L. Yuan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

E. L. Sausville· 3 shared J. M. Sheltzer· 3 shared V. Girish· 3 shared J. C. Smith· 2 shared A. A. Lakhani· 1 shared A. Ghosh· 1 shared A. M. Taylor· 1 shared A. R. Chait· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

E. L. Sausville

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Oncogene-like addiction to aneuploidy in human cancers

V. Girish, A. A. Lakhani, C. M. Scaduto, S. L. Thompson, L. M. Brown, R. A. Hagenson, E. L. Sausville, B. E. Mendelson, D. A. Lukow, M. L. Yuan, P. K. Kandikuppa, E. C. Stevens, S. N. Lee, B. Salovska, W. Li, , J. M. Sheltzer

This study demonstrates that trisomy of chromosome 1q is essential for malignant growth in cancers and shows that TP53 mutations are mutually exclusive with 1q aneuploidy.

bioRxiv · Jan 9, 2023Cancer Biology

Combustible and electronic cigarette exposures increase ACE2 activity and SARS-CoV-2 Spike binding

A. Ghosh, V. Girish, M. L. Yuan, R. D. Coakley, N. E. Alexis, E. L. Sausville, A. Vasudevan, A. R. Chait, J. M. Sheltzer, R. Tarran

This study shows that combustible and electronic cigarette exposures increase ACE2 activity and SARS-CoV-2 Spike binding, potentially increasing infection risk.

American Journal of Respiratory and Critical Care Medicine · Jan 1, 2022Peer-reviewedPhysiology

Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tract

J. C. Smith, E. L. Sausville, V. Girish, M. L. Yuan, K. M. John, J. M. Sheltzer

This study shows cigarette smoke increases ACE2 expression in lung cells, making smokers more susceptible to severe SARS-CoV-2 infections.

bioRxiv · Mar 28, 2020Cell Biology