SUMOylation of ABCD3 restricts bile acid synthesis and regulates metabolic homeostasis
V. Goyon, A. Besse-Patin, R. Zunino, M. Nguyen, E. Coyaud, J. M. Lee, B. N. Nguyen, B. Raught, H. M. McBride
This study identifies MAPL's role in regulating bile acid synthesis and metabolic homeostasis, showing its loss leads to insulin sensitivity and hepatocellular carcinoma.
bioRxiv · Mar 3, 2022 · PreprintCell Biology