H. Xiao

Pure Nano Genesis: Pioneering Universal Aqueous Nanostrategies from Pure Molecules to Revolutionise Diverse Applications

This paper introduces a novel method for creating stable aqueous nanoparticles from pure conjugated molecules, demonstrating their efficacy in treating various diseases in vivo.

The Impact of Anesthesia on Ultrasonic Glymphatic Perturbation Protocol: Alertness, and Glymphatic Influx

This study evaluates how isoflurane-induced anesthesia affects ultrasonically enhanced glymphatic transport in rats, finding that lighter anesthesia improves transport efficiency.

Dual-targeted nanoparticulate drug delivery systems for enhancing triple-negative breast cancer treatment

This paper develops a dual-targeted nanoparticulate drug delivery system (SJNP) combining SN38 and JQ-1 to enhance triple-negative breast cancer treatment by disrupting DNA repair and mitochondrial function.

A comprehensive landscape of the zinc-regulated human proteome

This study maps zinc-regulated cysteine sites in the human proteome, identifies cancer dependencies, and reveals a mechanism of zinc-induced cytotoxicity in lung cancers.

Uncovering Minimal Pathways in Melanoma Initiation

This study identifies LNM cells as a pre-malignant state in melanoma initiation, showing they pre-exist in normal skin, expand with Braf activation, and contribute to drug resistance.

Floral scent emission of Epiphyllum oxypetalum: identification of a novel cytosol-localized geraniol biosynthesis pathway

This study identifies a novel cytosol-localized geraniol biosynthesis pathway in Epiphyllum oxypetalum using volatilomic, transcriptomic, and biochemical approaches.

Instant Assembly of Collagen for Scaffolding, Tissue Engineering, and Bioprinting

This paper introduces TRACE, a method for instant collagen gelation and patterning, enabling applications in biofabrication and tissue engineering.

Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity

The paper presents cryo-EM structures of human SIDT1 and SIDT2, revealing their dimeric architecture and demonstrating low-pH-dependent RNA binding and oligomerization.

A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus

This study identifies a novel human antibody, AF-03, that targets MARV glycoprotein and shows neutralizing activity against MARV and related filoviruses.

Characterization of N-glycosylation and its Functional Role in SIDT1-Mediated RNA Uptake

This study maps N-glycosylation sites in SIDT1 and SIDT2 and shows their role in RNA uptake, cell surface expression, and protein stability.

BRD4 directs mitotic cell division by inhibiting DNA damage

This study shows BRD4 is essential for normal cell growth by regulating cell cycle genes and preventing DNA damage during replication and mitosis.

Tempered IL-2 Signals Program PD-1 Checkpoint Blockade-Responsive Stem-like Exhausted T Cells During Priming

This study shows that tempered IL-2 signals promote the development of PD-1 checkpoint blockade-responsive stem-like exhausted CD8 T cells during priming, while strong IL-2 signals drive terminal differentiation.

Rice OsHAK18 mediates shoot-to-root circulation of potassium and sodium and source-to-sink transport of soluble sugar

Rice OsHAK18 mediates shoot-to-root potassium and sodium circulation and source-to-sink sugar transport, improving potassium use efficiency and grain yield.

Monocarboxylate transporters facilitate succinate uptake into brown adipocytes

This study identifies monocarboxylate transporters (MCTs) as facilitators of succinate uptake into brown adipocytes, showing their role in metabolic disease protection.

Genomic deletion of Bcl6 differentially affects conventional dendritic cell subsets and compromises Tfh/Tfr/Th17 cell responses

Gut microbiota-derived tryptamine impairs insulin sensitivity

This study identifies tryptamine, a gut microbiota-derived metabolite, as a contributor to insulin resistance in type 2 diabetes through TAAR1-ERK signaling.

Phenethylamine-producing gut bacteria induces diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis

This study identifies Ruminococcus gnavus as a gut bacterium that contributes to IBS-D by increasing serotonin biosynthesis through phenethylamine production.

Mechanisms of frustrated phagocytic spreading of human neutrophils on antibody-coated surfaces

The paper analyzes neutrophil spreading on antibody-coated surfaces, finding that cytoskeletal forces, not adhesion, primarily drive phagocytic spreading.

The sowing date changed the temperature and light conditions in the field modified the cadmium content of brown rice (Oryza sativa L.) by regulating the expression of Cd-related genes

This study shows that sowing date affects temperature and light conditions during rice growth, which in turn modifies cadmium content in brown rice by regulating Cd-related gene expression.

Expansion and Adaptive Evolution of the mTERF Gene Family in Plants

The paper analyzes the expansion and adaptive evolution of mTERF genes in plants, finding that M-class mTERF genes expanded via tandem duplication and evolved rapidly with positive selection in nucleic acid-binding sites.

KRAS G12D can be targeted by potent salt-bridge forming inhibitors

This study identifies potent inhibitors targeting KRAS G12D via a salt-bridge interaction, showing efficacy in reducing tumor volume and synergizing with anti-PD-1 therapy.

Metabolomic and transcriptomic analyses reveal the effects of grafting on anthocyanin synthesis in grapevine

This study investigates how grafting affects anthocyanin synthesis in grapevines by analyzing metabolomic and transcriptomic profiles across different grafting conditions.

Structures of plasmepsin X from P. falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme

The paper reports the crystal structure of PfPMX zymogen, revealing a novel inactivation mechanism and molecular basis for inhibitor binding in the mature enzyme.

Mechanical stimulation promotes enthesis injury repair by mobilizing Prx1+ cells via ciliary TGF-β signaling

Bone-Specific Enhancement of Antibody Therapy for Breast Cancer Metastasis to Bone

This paper enhances antibody therapy for breast cancer bone metastasis by engineering antibodies with bone-homing peptides, improving their bone tumor targeting and therapeutic efficacy.

Harnessing the Power of Antibodies to Fight Bone Metastasis

This paper develops a bone-targeting antibody using bisphosphonate conjugation and demonstrates its enhanced efficacy against bone metastases in xenograft models.

Evaluation of exosome-encapsulated miR-23a/b in the diagnosis of human coronary heart diseases

This study evaluates serum exosomal miR-23a and miR-23b as biomarkers for diagnosing coronary heart diseases, finding miR-23a is downregulated and predictive of stable angina and AMI.

Scavenger receptor A1 participates in the phagocytosis of Leptospira interrogans and leads to subsequent high inflammatory responses and bacterial dissemination in leptospirosis

This study shows that SR-A1 facilitates Leptospira phagocytosis by macrophages but also promotes bacterial dissemination and inflammation, worsening leptospirosis in mice.

Skeletal muscle DNMT3A plays a necessary role in endurance exercise by regulating oxidative capacity of red muscles

This study shows that DNMT3A in skeletal muscle regulates oxidative capacity and endurance exercise by controlling ROS production through ALDH1L1.

Blocking antibodies against SARS-CoV-2 RBD isolated from a phage display antibody library using a competitive biopanning strategy

This paper isolates blocking antibodies against SARS-CoV-2 RBD using a competitive biopanning strategy, identifying a high-affinity antibody with potent neutralizing activity.