Author

V. Hoikkala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:bacteria (other)· 4 Assay:whole-genome sequencing· 3 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:Drosophila· 1

Frequent Co-Authors

L.-R. Sundberg· 4 shared J. J. Ravantti· 2 shared A. Runtuvuori-Salmela· 1 shared C. Diez-Villasenor· 1 shared D. R. Laetsch· 1 shared E. Laanto· 1 shared G. M. Almeida· 1 shared H. Chi· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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4 shared papersMicrobiology

L.-R. Sundberg

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Antiviral Type III CRISPR signalling via conjugation of ATP and AdoMet

H. Chi, V. Hoikkala, S. Gruschow, S. Graham, S. Shirran, M. F. White

This study identifies SAM-AMP as a novel second messenger in type III-B CRISPR systems, used for antiviral signaling by conjugating ATP to S-adenosyl methionine.

bioRxiv · Jun 26, 2023 · PreprintMicrobiology

Chromosomal inversions and the demography of speciation in Drosophila montana and Drosophila flavomontana

N. Poikela, D. R. Laetsch, V. Hoikkala, K. Lohse, M. Kankare

This study examines chromosomal inversions in Drosophila montana and D. flavomontana, finding that inversions were present in the common ancestor and reduced gene flow between species, potentially aiding speciation.

bioRxiv · Nov 15, 2022Evolutionary Biology

Mucin induces CRISPR-Cas defence in an opportunistic pathogen

G. M. Almeida, V. Hoikkala, J. J. Ravantti, N. Rantanen, L.-R. Sundberg

The paper shows that mucin enhances CRISPR spacer acquisition in Flavobacterium columnare during phage infection, especially under low nutrient conditions and in the presence of competitor bacteria.

bioRxiv · Aug 10, 2021 · PreprintMicrobiology

Bacteriophage Resistance Affects Flavobacterium columnare Virulence Partly via Mutations in Genes Related to Gliding Motility and Type IX Secretion System

H. M. Kunttu, A. Runtuvuori-Salmela, K. Sundell, T. Wiklund, M. Middelboe, L. Landor, R. Ashrafi, V. Hoikkala, L.-R. Sundberg

This study shows that phage resistance in Flavobacterium columnare reduces virulence, making phage therapy viable for treating columnaris disease in aquaculture.

bioRxiv · Oct 2, 2020Microbiology

Cooperation between CRISPR-Cas types enables adaptation in an RNA-targeting system

V. Hoikkala, J. J. Ravantti, C. Diez-Villasenor, M. Tiirola, R. Conrad, M. J. McBride, L.-R. Sundberg

The paper shows that an RNA-targeting CRISPR-Cas subtype VI-B locus can acquire spacers using machinery from a DNA-targeting II-C locus in the same bacterium.

bioRxiv · Feb 20, 2020Microbiology

Long-term genomic coevolution of host-parasite interaction in the natural environment

E. Laanto, V. Hoikkala, J. Ravantti, L.-R. Sundberg

This study investigates long-term host-parasite coevolution in natural environments using bacteriophage and bacterial genomic data, revealing dynamic molecular interactions and resistance mechanisms.

bioRxiv · Jan 21, 2017Microbiology