M. J. McBride

Reprogramming neuroblastoma by diet-enhanced polyamine depletion

This paper shows that combining dietary restriction of arginine and proline with polyamine depletion drugs enhances tumor differentiation and survival in a neuroblastoma mouse model by disrupting oncogenic translation.

Synergistic Binding of the Halide and Cationic Prime Substrate of the L-Lysine 4-Chlorinase, BesD, in Both Ferrous and Ferryl States

This paper investigates the synergistic binding of halide and cationic substrates in the BesD enzyme across different iron states, revealing cooperative interactions and decay pathways.

Glycine homeostasis requires reverse SHMT flux

The paper shows that SHMT flux consumes glycine rather than producing it, with liver SHMT2 playing a major role in glycine consumption.

In situ structure and organisation of the type IX secretion system

The paper uses cryo-electron tomography and proteomics to study the structure and organisation of the type IX secretion system in Bacteroidetes, identifying new interactions and proposing a model for substrate secretion.

A Substrate-triggered μ-Peroxodiiron(III) Intermediate in the 4-Chloro-L-Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate

The paper characterizes a substrate-triggered μ-peroxodiiron(III) intermediate in the enzyme BesC, showing it initiates oxidative fragmentation by abstracting hydrogen from C4 and allowing substrate dissociation.

Convergent selection on juvenile hormone signaling is associated with the evolution of eusociality in bees

The paper identifies genomic signatures and loci associated with convergent gains and losses of eusociality in sweat bees, linking them to juvenile hormone signaling proteins.

Structure and assembly of the diiron cofactor in the heme-oxygenase-like domain of the N-nitrosourea-producing enzyme SznF

This paper investigates the assembly of the diiron cofactor in the SznF enzyme, revealing structural changes and an unexpected glutamate ligand that aids in function assignment.

Cooperation between CRISPR-Cas types enables adaptation in an RNA-targeting system

The paper shows that an RNA-targeting CRISPR-Cas subtype VI-B locus can acquire spacers using machinery from a DNA-targeting II-C locus in the same bacterium.

Opposing immune and genetic forces shape oncogenic programs in synovial sarcoma

The paper profiles synovial sarcoma tumors to show that the SS18-SSX fusion drives oncogenic programs, which are repressed by immune cells and can be targeted with HDAC and CDK4/6 inhibitors.