W. Mwangi

HIV envelope trimers and gp120 as immunogens to induce broadly neutralizing antibodies in cows

This study investigates whether engineering HIV Env trimers or using gp120 can induce broadly neutralizing antibodies in cows, finding that trimers are more effective than monomeric gp120.

Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire

This study immunized cows with HIV Env trimers to generate broadly neutralizing antibodies targeting the V2-apex, revealing ultralong CDRH3 antibodies outcompete shorter ones in the response.

Ability of mycobacterial pathogens to establish a persistent infection is lost by deletion of a single gene, rel, regulator of the stringent response

The paper shows deletion of the rel gene in mycobacterial pathogens prevents persistent infection and impairs CD8 T cell responses in cattle, but not the timing or cytokine expression of the response.

Minor differences in peptide presentation between chicken MHC class I molecules can explain differences in disease susceptibility

The paper shows that differences in peptide binding between chicken MHC class I alleles BF2*1901 and BF2*1501 explain their differing susceptibility to Mareks disease.

Optimized Multicolour Immunofluorescence Panel for Cattle T Cell Phenotyping by an 8-Colour, 10-Parameter Panel

This paper develops an 8-color, 10-parameter flow cytometry panel to identify cattle T cell subsets and their activation states, improving the study of immune responses in cattle.

Optimized Multicolour Immunofluorescence Panel for Cattle B Cell Phenotyping by an 8-Colour, 10-Parameter Panel

This paper optimizes an 8-color, 10-parameter immunofluorescence panel to identify five functionally distinct B cell subsets in cattle PBMCs.

Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans

This study generates pig-specific monoclonal antibodies against H1N1pdm09 influenza virus that target human-like HA epitopes and reduce disease severity in pigs.