Isoform-specific aPKC renders primary cilia dispensable for Hedgehog signaling and basal cell carcinoma growth
T. T. Nguyen, K. Wong, U. S. Jeon, V. Jhumkhawala, D. Luy, K. C. Tan, I. Wickramatunga, V. Kumar, W. E. England, L. T. Doan, R. C. Spitale, S. X. Atwood
The paper shows that aPKC isoforms sustain HH signaling and BCC growth without primary cilia by compensating for ciliary loss in advanced cancers.
bioRxiv · Jun 8, 2020 · PreprintCancer Biology