S. X. Atwood

This study shows that ERK2 phosphorylates GLI1 at three sites, weakening its binding to SUFU and enhancing GLI1 activation, contributing to Hedgehog-MAPK pathway crosstalk in cancer.

This study uses single-cell RNA sequencing to show heat shock proteins promote BCC growth in response to WNT5A-mediated inflammatory signals from the tumor microenvironment.

The paper identifies MTOR as a driver of basal cell carcinoma growth by activating aPKC, showing that MTOR inhibition reduces tumor growth in mouse models.

The paper shows that aPKC isoforms sustain HH signaling and BCC growth without primary cilia by compensating for ciliary loss in advanced cancers.