V. Kumra Ahnlide

Invasive streptococcal infection can lead to the generation of cross-strain opsonic antibodies

This study examines opsonic antibody responses to invasive S. pyogenes infections, finding modest increases in antibody binding and variable opsonic capacity across strains.

Group A streptococci induce high-affinity M protein-fibronectin interaction when specific human antibodies are bound

The paper shows that human antibodies can enhance the Fn-binding affinity of GAS M proteins by targeting a conserved region, allowing bacteria to bind Fn more efficiently without producing additional proteins.

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein protects against infection

The paper describes a human monoclonal antibody that binds two distinct epitopes on streptococcal M protein via a bivalent dual-Fab cis mode, providing protection against infection.

Binding site localization on non-homogeneous cell surfaces using topological image averaging

This paper develops a method for imaging-based localization of antibody binding sites on cell surfaces, achieving nanometer-scale resolution through topological image averaging.

A predictive model of antibody binding in the presence of IgG-interacting bacterial surface proteins

The paper develops a biophysical model to predict antibody binding interactions with bacterial surface proteins and demonstrates its utility in predicting IgG treatment effects.