Author

V. M. Olkkonen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1

Frequent Co-Authors

A. Arora· 1 shared A. Brech· 1 shared A. H. Lystad· 1 shared A. Houcine· 1 shared A. M. Kivela· 1 shared C. Raiborg· 1 shared C. Sauvanet· 1 shared D. Tareste· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCell Biology

A. Arora

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Author profile →

4 papers

Recent·Most cited

One-step generation of auxin-inducible degron cells with high-efficiency homozygous tagging

S. Li, Y. Wang, M. v. d. Stoel, X. Zhou, S. Madhusudan, K. Kanerva, V. D. Nguyen, N. Eskici, V. M. Olkkonen, Y. Zhou, T. Raivio, E. Ikonen

This paper introduces a one-step genome editing method for high-efficiency homozygous tagging of endogenous proteins with auxin-inducible degron in human cells, achieving >80% efficiency in A431 cells and >50% in H9 ES cells.

bioRxiv · Mar 26, 2023 · PreprintCell Biology

Lysosome repair by ER-mediated cholesterol transfer

M. Radulovic, E. M. Wenzel, S. Gilani, L. K. K. Holland, A. H. Lystad, S. Phuyal, V. M. Olkkonen, A. Brech, M. Jäättelä, K. Maeda, C. Raiborg, H. Stenmark

The paper identifies an ER-mediated cholesterol transfer mechanism for lysosome repair independent of ESCRTs, involving PI4K2A and OSBP.

bioRxiv · Sep 26, 2022 · PreprintCell Biology

ORP5/8 AND MIB/MICOS LINK ER-MITOCHONDRIA AND INTRAMITOCHONDRIAL CONTACTS FOR NON-VESICULAR TRANSPORT OF PHOSPHATIDYLSERINE

V. F. Monteiro-Cardoso, L. Rochin, A. Arora, A. Houcine, E. Jaaskelainen, A. M. Kivela, C. Sauvanet, R. Le Bars, E. Marien, J. Dehairs, J. Neveu, N. El Khallouki, E. Santonico, J. V. Swinnen, D. Tareste, , F. Giordano

The paper identifies ORP5/8 and MIB/MICOS complexes as mediators of non-vesicular phosphatidylserine transport between ER and mitochondria via membrane contact sites.

bioRxiv · May 25, 2022Cell Biology

Human adipocyte differentiation and composition of disease relevant lipids are regulated by miR-221-3p

M. A. Ahonen, M. Y. Asghar, S. J. Parviainen, G. Liebisch, M. Höring, M. Leidenius, P. Fischer-Posovszky, M. Wabitsch, T. S. Mikkola, K. Törnquist, H. Savolainen-Peltonen, P. A. N. Haridas, V. M. Olkkonen

This study shows miR-221-3p inhibits adipocyte differentiation and alters lipid composition, linking it to metabolic diseases and cancer progression.

bioRxiv · Jun 30, 2020Cell Biology