J. V. Swinnen

Integrating multiple omics levels using the human protein complexome as a framework, a multi-omics study of inborn errors of metabolism

This study integrates proteomics, transcriptomics, and metabolomics data from IEM patients to identify perturbed protein complexes and pathways, highlighting mitochondrial oxidative phosphorylation and histone acetylation dysregulation.

Integration of Multiple Spatial-Omics Modalities Reveals Unique Insights into Molecular Heterogeneity of Prostate Cancer

This paper integrates multiple spatial-omics modalities in prostate cancer samples to reveal molecular heterogeneity and correlations between lipids and gene expression.

Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer

This study identifies DECR2 as a key driver of treatment resistance in advanced prostate cancer by regulating lipid metabolism and cell cycle progression.

Disrupting peroxisomes alters lipid metabolism in melanoma and uncovers a novel therapeutic vulnerability in combination with MAPK-targeted therapies

This paper identifies a metabolic vulnerability in melanoma cells by disrupting peroxisomes and shows that combining this with MAPK-targeted therapies enhances anti-tumor effects.

ACSM1 and ACSM3 regulate prostate cancer fatty acid metabolism to promote tumour growth and constrain ferroptosis

This study identifies ACSM1 and ACSM3 as AR-regulated factors that promote prostate cancer growth by enhancing fatty acid metabolism and suppressing ferroptosis.

Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity

This study shows that SCD1 inhibits Treg differentiation and promotes autoimmunity by affecting fatty acid metabolism in an MS model.

ORP5/8 AND MIB/MICOS LINK ER-MITOCHONDRIA AND INTRAMITOCHONDRIAL CONTACTS FOR NON-VESICULAR TRANSPORT OF PHOSPHATIDYLSERINE

The paper identifies ORP5/8 and MIB/MICOS complexes as mediators of non-vesicular phosphatidylserine transport between ER and mitochondria via membrane contact sites.

Lipidomic profiling of clinical prostate cancer reveals targetable alterations in lipid composition

The paper profiles lipidomes in prostate cancer tissues and identifies targetable lipid alterations linked to AR signaling and therapeutic response.

Alpha-ketoglutarate inhibits Regulatory T cell differentiation by coupling lipidome remodelling to mitochondrial metabolism

This study shows that alpha-ketoglutarate inhibits regulatory T cell differentiation by altering lipid metabolism and mitochondrial function.

Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer

This study identifies therapy-induced lipid uptake and remodeling as drivers of ferroptosis hypersensitivity in prostate cancer, offering new strategies to combat drug resistance.

DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

This study identifies DECR1 as an androgen-repressed gene that promotes prostate cancer cell survival by facilitating PUFA oxidation and preventing ferroptosis.

Cell density-dependent ferroptosis in breast cancer is induced by accumulation of polyunsaturated fatty acid-enriched triacylglycerides

This study shows that low cell density in breast cancer cells increases ferroptosis sensitivity by promoting PUFA-enriched TAG accumulation and reducing lipid desaturation.