V. M. Tan

Saracatinib synergizes with enzalutamide to downregulate androgen receptor activity in castration resistant prostate cancer

This study shows that combining saracatinib with enzalutamide reduces androgen receptor activity and DNA replication in CRPC cell lines, leading to increased apoptosis.

Massively parallel, computationally-guided design of a pro-enzyme

This paper designs pro-enzymes using computational methods and validates their activity regulation through protease cleavage.