Pharmacological inhibition of HDAC6 downregulates TGF-β via Smad2/3 acetylation and improves dystrophin-deficient muscles.
A. Osseni, A. Ravel-Chapuis, I. Scionti, Y.-G. Gangloff, V. Moncollin, R. Mounier, P. Leblanc, B. J. Jasmin, L. Schaeffer
This study shows that inhibiting HDAC6 with tubastatin A improves dystrophin-deficient muscle by reducing fibrosis and restoring microtubules and NMJ through Smad2/3 acetylation and TGF-β signaling inhibition.
bioRxiv · Jan 21, 2022 · PreprintPhysiology