R. Mounier

Polymeric nanoparticles delivery of AMPK activator 991 prevents its toxicity and improves muscle homeostasis in Duchenne Muscular Dystrophy

This paper shows that delivering AMPK activator 991 via polymeric nanoparticles reduces toxicity and improves muscle homeostasis in a DMD mouse model.

Impaired skeletal muscle regeneration induced by Cre recombinase activation in skeletal muscle stem cells

This study shows that Cre recombinase activation in skeletal muscle stem cells impairs muscle regeneration, highlighting off-target effects of Pax7CreERT2 mice.

Metformin protects the heart against chronic intermittent hypoxia through AMPK-dependent phosphorylation of HIF-1α

This study shows metformin protects the heart from chronic intermittent hypoxia by activating AMPK2, which phosphorylates and inhibits HIF-1α, reducing mitochondrial damage.

Alterations of the TGFb-sequestration complex member ADAMTSL1 levels are associated with muscular defects and rhabdomyosarcoma aggressiveness

This study shows ADAMTSL1 is involved in skeletal muscle regeneration and acts as a prognostic factor in aggressive rhabdomyosarcoma, correlating with a neural-like phenotype.

AMPKα2 is a skeletal muscle stem cell intrinsic regulator of myonuclear accretion

This study shows that AMPKα2 regulates myonuclear accretion in muscle stem cells, essential for muscle regeneration.

Pharmacological inhibition of HDAC6 downregulates TGF-β via Smad2/3 acetylation and improves dystrophin-deficient muscles.

This study shows that inhibiting HDAC6 with tubastatin A improves dystrophin-deficient muscle by reducing fibrosis and restoring microtubules and NMJ through Smad2/3 acetylation and TGF-β signaling inhibition.

Myofiber / pro-inflammatory macrophage interplay controls muscle damage in mdx mice

This study shows that dystrophic myofibers promote pro-inflammatory macrophage polarization, leading to muscle damage, and that H2S donors can reduce inflammation and fibrosis in mdx mice.

GREM1 is epigenetically reprogrammed in muscle cells after exercise training and controls myogenesis and metabolism

This study identifies an epigenetic reprogramming of GREM1 in muscle cells after exercise training, which enhances myogenesis and metabolism through the AMPK pathway.

AMPKα1 is essential for Glucocorticoid Receptor triggered anti-inflammatory macrophage activation

This study shows that AMPKα1 is required for glucocorticoid receptor-mediated anti-inflammatory macrophage activation, linking metabolism to inflammation resolution.

Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation

This study identifies Annexin A1 as a driver of macrophage polarization towards a resolving phenotype via AMPK activation, enhancing muscle regeneration after injury.