Pathogen diversity drives the evolution of promiscuous peptide binding of human MHC-II alleles
M. Manczinger, G. Boross, L. Kemeny, V. Muller, T. Lenz, B. Papp, C. Pal
This study shows that pathogen diversity drives the evolution of promiscuous peptide binding in human MHC-II alleles, explaining their global distribution and immune function.
bioRxiv · Jul 17, 2018Evolutionary Biology