Author

T. Lenz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 4 Cell Biology· 2 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:chromatin & epigenetic regulation· 6 Approach:experimental assay· 5 Organism:human· 5 Assay:DNA methylation· 3 Research Focus:drug response / drug discovery· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

K. G. Le Roch· 4 shared S. Abel· 4 shared J. Prudhomme· 3 shared M. Gupta· 3 shared S. Lonardi· 3 shared A. Sanchez-Flores· 2 shared C. Ben Mamoun· 2 shared E. Cornillot· 2 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

K. G. Le Roch

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Epigenetics and chromatin structure regulate var2csa expression and the placental binding phenotype in Plasmodium falciparum

T. Lenz, M. Sirel, H. Hoppe, S. Shafeeq, K. Le Roch, U. Ribacke

The paper investigates how epigenetics and chromatin structure regulate var2csa expression and placental binding in Plasmodium falciparum, identifying H3K9me3 depletion and chromatin repositioning as key factors.

eLife · Apr 15, 2026Peer-reviewedCell Biology

Development of a Bipyrimidineamide based α-Helix Mimetic Lead Compound for efficient Targeting of MDM2 in Triple-Negative Breast Cancer

J. L. On, V. Woloschin, F. Gier, J.-W. Tu, S. Bhatia, T. Lenz, K. Stühler, D. Niederacher, H. Neubauer, T. Fehm, T. Kurz, K. Esser

This study develops a bipyrimidineamide-based α-helix mimetic compound, VWK603, which effectively targets MDM2 in TNBC cells with lower toxicity than Nutlin-3a.

bioRxiv · Mar 2, 2024 · PreprintCancer Biology

Multiomics analysis reveals B. MO1 as a distinct Babesia species and provides insights into its evolution and virulence.

P. Singh, P. Vydyam, T. Fang, M. Kumar, K. Estrada, R. Grande, A. Sanchez-Flores, L. M. Gonzalez, E. Montero, S. Chakravarty, S. Lonardi, V. Berry, V. Ranwez, B. Carcy, D. Depoix, , C. Ben Mamoun

The paper identifies B. MO1 as a distinct Babesia species through multiomics analysis, revealing genomic and functional differences from B. divergens and insights into their evolution and virulence.

bioRxiv · Jan 17, 2024Microbiology

PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum

Z. M. Chahine, M. Gupta, T. Lenz, T. Hollin, S. Abel, C. Banks, A. Saraf, J. Prudhomme, S. Bhanvadia, L. Florens, K. G. Le Roch

This study shows PfMORC regulates chromatin structure and gene repression in Plasmodium falciparum, essential for parasite survival and a potential target for antimalarial drugs.

bioRxiv · Sep 11, 2023Microbiology

A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites

S. P. Maher, M. A. Bakowski, A. Vantaux, E. L. Flannery, C. Andolina, M. Gupta, Y. Antonova-Koch, M. Argomaniz, C.-M. Monica, C. Brice, A. T. Chao, A. K. Chatterjee, W. T. Cheng, E. Chuenchob, C. A. Cooper, , McNama

The paper identifies epigenetic inhibitors active against Plasmodium vivax hypnozoites through drug repurposing screens, showing epigenetic pathways are critical for hypnozoite quiescence.

bioRxiv · Jan 31, 2023 · PreprintCell Biology

Deciphering the non-coding code of pathogenicity and sexual differentiation in the human malaria parasite.

G. Batugedara, X. M. Lu, S. Abel, Z. Chahine, B. Hristov, D. Williams, T. Hollin, T. Wang, A. Cort, T. Lenz, T. Thompson, J. Prudhomme, A. K. Tripathi, G. Xu, J. Cudini, , K. G. Le Roch

This study identifies and characterizes long non-coding RNAs (lncRNAs) in Plasmodium falciparum, revealing their role in gene regulation, pathogenicity, and sexual differentiation.

bioRxiv · Oct 12, 2022 · PreprintMicrobiology

Decoding The Nuclear Genome of The Human Pathogen Babesia duncani Shed Light on its Virulence, Drug Susceptibility and Evolution among Apicomplexa

S. Lonardi, P. Singh, Q. Liang, P. Vydyam, E. Khabirova, T. Fang, S. Gihaz, J. Thekkiniath, M. Munshi, S. Abel, G. Batugedara, M. Gupta, X. M. Lu, T. Lenz, S. Chakravarty, , C. Ben Mamoun

This study decodes the nuclear genome of Babesia duncani, identifies virulence factors and drug targets, and discovers potent inhibitors for treating babesiosis.

bioRxiv · May 9, 2022Microbiology

Pathogen diversity drives the evolution of promiscuous peptide binding of human MHC-II alleles

M. Manczinger, G. Boross, L. Kemeny, V. Muller, T. Lenz, B. Papp, C. Pal

This study shows that pathogen diversity drives the evolution of promiscuous peptide binding in human MHC-II alleles, explaining their global distribution and immune function.

bioRxiv · Jul 17, 2018Evolutionary Biology