Cancer cells adapt FAM134B-BiP complex mediated ER-phagy to survive hypoxic stress
S. Chipurupalli, R. Ganesan, G. Martini, L. Mele, E. Kannan, V. Namasivayam, V. Desiderio, N. Robinson
This study shows cancer cells use the FAM134B-BiP complex to trigger ER-phagy under hypoxia, enabling survival, and identifies vitexin as a drug that blocks this process to inhibit breast cancer.
bioRxiv · Feb 5, 2021Cancer Biology