Optogenetic dissection of transcriptional repression in a multicellular organism
J. Zhao, N. C. Lammers, S. Alamos, Y. J. Kim, G. Martini, H. G. Garcia
This study uses optogenetics and mathematical modeling to show that the zinc-finger repressor Knirps rapidly and memorylessly represses gene expression by reducing transcriptional burst frequency.
Nature Communications · Oct 26, 2024Peer-reviewedBiophysics