Pyruvate metabolism dictates fibroblast sensitivity to GLS1 inhibition during fibrogenesis
G. Contento, J.-A. A. Wilson, B. Selvarajah, M. Plate, D. Guillotin, V. Morales, M. Trevisani, V. Pitozzi, K. Bianchi, R. C. Chambers
This study shows that pyruvate metabolism affects fibroblast response to GLS1 inhibition during fibrosis, suggesting combined targeting of pyruvate metabolism and glutaminolysis as a therapeutic strategy.
bioRxiv · Jan 30, 2024Cell Biology