Author

R. C. Chambers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. J. Fisher· 1 shared A. Nazgiewicz· 1 shared A. Pinto· 1 shared A. S. Loudon· 1 shared A. Saleh· 1 shared A.-M. Cujba· 1 shared B. Hinz· 1 shared B. Selvarajah· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperCell Biology

A. J. Fisher

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Author profile →

3 papers

Recent·Most cited

Pyruvate metabolism dictates fibroblast sensitivity to GLS1 inhibition during fibrogenesis

G. Contento, J.-A. A. Wilson, B. Selvarajah, M. Plate, D. Guillotin, V. Morales, M. Trevisani, V. Pitozzi, K. Bianchi, R. C. Chambers

This study shows that pyruvate metabolism affects fibroblast response to GLS1 inhibition during fibrosis, suggesting combined targeting of pyruvate metabolism and glutaminolysis as a therapeutic strategy.

bioRxiv · Jan 30, 2024Cell Biology

The emergence of goblet inflammatory or ITGB6hi nasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis

M. Woodall, A.-M. Cujba, K. B. Worlock, K.-M. Case, T. Masonou, M. Yoshida, K. Polanski, N. Huang, R. G. Lindeboom, L. Mamanova, L. Bolt, L. Richardson, S. Ellis, M. Palor, T. Burgoyne, , C. M. Smith

The study identifies age-related differences in nasal epithelial cell responses to SARS-CoV-2 infection, showing distinct progenitor cell dynamics in children and elderly.

bioRxiv · Jan 16, 2023 · PreprintCell Biology

The circadian clock protein REVERBα inhibits pulmonary fibrosis development

P. S. Cunningham, P. Meijer, A. Nazgiewicz, S. G. Anderson, L. A. Borthwick, J. Bagnall, G. B. Kitchen, M. Lodyga, N. Begley, R. V. Venkateswaran, R. Shah, P. F. Mercer, H. J. Durrington, N. C. Henderson, K. Piper-Hanley, , J. Blaikley

This study identifies REVERBα as a regulator of pulmonary fibrosis by modulating circadian rhythms and integrin β1 focal adhesion formation in fibroblasts, with potential therapeutic implications.

bioRxiv · Sep 25, 2019Cell Biology