Author

A. Wickenhagen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

S. J. Wilson· 4 shared A. da Silva Filipe· 3 shared D. Mair· 2 shared E. C. Thomson· 2 shared F. Grey· 2 shared J. Hughes· 2 shared L. Tong· 2 shared M. L. Turnbull· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersMicrobiology

S. J. Wilson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Zoonotic avian influenza viruses evade human BTN3A3 restriction

R. M. Pinto, S. Bakshi, S. Lytras, M. K. Zakaria, S. Swingler, J. C. Worrell, V. Herder, M. Varjak, N. Cameron-Ruiz, M. Collados-Rodriguez, M. Varela, A. Wickenhagen, C. Loney, Y. Pei, J. Hughes, , M. Palmarini

This study identifies BTN3A3 as a human restriction factor that inhibits avian influenza viruses but not human IAVs, with resistance linked to specific NP mutations.

bioRxiv · Jun 14, 2022 · PreprintMicrobiology

The Interferon Resistance of Transmitted HIV-1 is a Consequence of Enhanced Replicative Fitness

E. Sugrue, A. Wickenhagen, N. Mollentze, M. A. Aziz, V. B. Sreenu, S. Truxa, L. Tong, A. da Silva Filipe, D. L. Robertson, J. Hughes, S. J. Rihn, S. J. Wilson

The paper identifies that transmitted HIV-1's interferon resistance stems from enhanced replicative fitness rather than specific IFN resistance.

bioRxiv · Dec 18, 2021Microbiology

In vitro evolution of Remdesivir resistance reveals genome plasticity of SARS-CoV-2

A. M. Szemiel, A. Merits, R. J. Orton, O. MacLean, A. Wickenhagen, G. Lieber, R. M. Pinto, M. L. Turnbull, S. Wang, D. Mair, A. da Silva Filipe, B. J. Willett, S. J. Wilson, A. H. Patel, E. C. Thomson, , M. E. Stewart

This study shows that in vitro evolution of SARS-CoV-2 under remdesivir selects for resistant mutations, but these mutations do not spread widely in global variants.

bioRxiv · Feb 1, 2021Microbiology

The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity

E. C. Thomson, L. E. Rosen, J. G. Shepherd, R. Spreafico, A. da Silva Filipe, J. A. Wojcechowskyj, C. Davis, L. Piccoli, D. J. Pascall, J. Dillen, S. Lytras, N. Czudnochowski, R. Shah, M. Meury, N. Jesudason, , J. Nichols

The paper shows the N439K SARS-CoV-2 spike variant maintains replication fitness while evading antibody neutralization.

bioRxiv · Nov 4, 2020Microbiology

Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate early genes.

Y.-T. Lin, S. Chiweshe, D. McCormick, A. Raper, A. Wickenhagen, V. R. DeFilippis, E. Gaunt, P. Simmonds, S. J. Wilson, F. Grey

This study shows HCMV evades ZAP detection by suppressing CpG dinucleotides in its IE1 gene, and TRIM25 regulates ZAP isoform expression.

bioRxiv · Jan 7, 2020Microbiology