Author

V. Rotter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:protein folding & dynamics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

M. Oren· 2 shared A. A. Malik· 1 shared A. Tuval· 1 shared A.-C. Gingras· 1 shared C. F. Suarez· 1 shared D. Derovic· 1 shared D. Durocher· 1 shared D. Leshkowitz· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

M. Oren

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2 papers

Recent·Most cited

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

Y. Lu, T. Cho, S. Mukherjee, A. A. Malik, N. Gonzalez-Foutel, C. F. Suarez, D. Derovic, R. H. Oh, E. Langille, K. Al-Zahrani, Z. Lin, R. Tsai, V. Rotter, P. Ashton-Prolla, L. B. Chemes, , D. Schramek

This study uses CRISPR screens to identify factors regulating wild-type and mutant p53 stability, finding distinct regulators for different p53 mutants and their implications in cancer.

bioRxiv · Mar 13, 2022Cancer Biology

Pseudo-mutant p53 as a targetable phenotype of DNMT3A-mutated pre-leukemia

A. Tuval, Y. Brilon, H. Ezogy, Y. Moskovitz, T. Biezuner, D. Leshkowitz, T. M. Salame, M. D. Minden, P. Tal, V. Rotter, M. Oren, N. Kaushansky, L. I. Shlush

The paper identifies a pseudomutant p53 conformation in DNMT3A-mutated pre-leukemic HSPCs and shows that shifting to the wild-type conformation can eliminate these cells.

bioRxiv · May 30, 2021 · PreprintCancer Biology