Author

E. Langille

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

D. Schramek· 2 shared R. Tsai· 2 shared A. A. Malik· 1 shared A. Malik· 1 shared A.-C. Gingras· 1 shared C. F. Suarez· 1 shared C. R. French· 1 shared C. Tobin· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

D. Schramek

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

CBD can be combined with additional cannabinoids for optimal seizure reduction and requires GPR55 for its anticonvulsant effects

R. Kollipara, E. Langille, C. Tobin, C. R. French

This study shows CBD's anticonvulsant effects in zebrafish require GPR55 and are enhanced by combining it with other cannabinoids like THC and CBG.

bioRxiv · Feb 15, 2023 · PreprintPharmacology & Toxicology

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

Y. Lu, T. Cho, S. Mukherjee, A. A. Malik, N. Gonzalez-Foutel, C. F. Suarez, D. Derovic, R. H. Oh, E. Langille, K. Al-Zahrani, Z. Lin, R. Tsai, V. Rotter, P. Ashton-Prolla, L. B. Chemes, , D. Schramek

This study uses CRISPR screens to identify factors regulating wild-type and mutant p53 stability, finding distinct regulators for different p53 mutants and their implications in cancer.

bioRxiv · Mar 13, 2022Cancer Biology

Loss of epigenetic regulation disrupts lineage integrity, reactivatesmultipotency and promotes breast cancer

E. Langille, K. N. Al-Zahrani, Z. Ma, A. Malik, S. K. Loganathan, D. Trcka, J. Liu, K. Kozma, R. Tsai, K. Teng, R. Espin, S. Barutcu, T. Nguyen, R. Bremner, H. W. Jackson, , D. Schramek

This study identifies epigenetic regulators as tumor suppressors in breast cancer by showing their loss leads to lineage infidelity and reactivation of lactation programs.

bioRxiv · Oct 22, 2021 · PreprintCancer Biology