Author

T. Cho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:genetic perturbation / CRISPR· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

D. Durocher· 2 shared A. A. Malik· 1 shared A. Alvarez-Quilon· 1 shared A. K. Ling· 1 shared A. M. Heijink· 1 shared A. Martin· 1 shared A. McEwan· 1 shared A. Muir· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCancer Biology

D. Durocher

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mitochondrial One-Carbon Metabolism is Required for TGF-β-Induced Glycine Synthesis and Collagen Protein Production

A. Y. Meliton, R. Cetin-Atalay, Y. Tian, J. C. Szafran, K. W. D. Shin, T. Cho, K. A. Sun, P. S. Woods, O. R. Shamaa, B. Chen, A. Muir, G. M. Mutlu, R. B. Hamanaka

This study shows that mitochondrial one-carbon metabolism is essential for TGF-β-induced glycine synthesis and collagen production in lung fibroblasts, suggesting MTHFD2 inhibitors could treat IPF.

bioRxiv · Nov 7, 2023Cell Biology

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

Y. Lu, T. Cho, S. Mukherjee, A. A. Malik, N. Gonzalez-Foutel, C. F. Suarez, D. Derovic, R. H. Oh, E. Langille, K. Al-Zahrani, Z. Lin, R. Tsai, V. Rotter, P. Ashton-Prolla, L. B. Chemes, , D. Schramek

This study uses CRISPR screens to identify factors regulating wild-type and mutant p53 stability, finding distinct regulators for different p53 mutants and their implications in cancer.

bioRxiv · Mar 13, 2022Cancer Biology

A genetic map of the response to DNA damage in human cells

M. Olivieri, T. Cho, A. Alvarez-Quilon, K. Li, M. J. Schellenberg, M. Zimmermann, N. Hustedt, S. E. Rossi, S. Adam, H. Melo, A. M. Heijink, G. Sastre-Moreno, N. Moatti, R. Szilard, A. McEwan, , D. Durocher

The paper identifies 840 genes involved in the DNA damage response through CRISPR/Cas9 screens and highlights specific gene functions in DNA repair and toxicity mechanisms.

bioRxiv · Nov 18, 2019Cancer Biology