Author

K. M. Jude

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Bioengineering· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Assay:protein structure· 4 Research Focus:protein structure prediction· 4 Approach:deep learning· 3 Research Focus:protein design· 2 Research Focus:cell-cell communication· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

K. C. Garcia· 6 shared C. R. Glassman· 3 shared N. A. Caveney· 2 shared N. Tsutsumi· 2 shared A. Kassardjian· 1 shared A. Mobedi· 1 shared A. Sperberg· 1 shared A. Yang· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersBiochemistry

K. C. Garcia

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A general platform for targeting MHC-II antigens via a single loop

H. Du, J. Liu, K. M. Jude, X. Yang, Y. Li, B. Bell, H. Yang, A. Kassardjian, A. Mobedi, U. Parekh, A. Sperberg, J.-P. Julien, E. Mellins, K. C. Garcia, P. Huang

This paper introduces TRACeR-II, a platform for developing MHC-II binders using a single loop, demonstrating its versatility and applicability to SARS-CoV-2 peptides.

bioRxiv · Jan 26, 2024 · PreprintBioengineering

De novo design of buttressed loops for sculpting protein functions

H. Jiang, K. M. Jude, K. Wu, J. Fallas, G. Ueda, T. Brunette, D. Hicks, H. Pyles, A. Yang, L. Carter, M. Lamb, X. Li, P. M. Levine, L. J. Stewart, K. C. Garcia, D. Baker

This paper designs proteins with structured loops supported by hydrogen bonds, demonstrating their stability and functionality in binding extended peptides.

bioRxiv · Aug 22, 2023 · PreprintBiochemistry

AlphaFold2 enables accurate deorphanization of ligands to single-pass receptors

N. Banhos Danneskiold-Samsoee, D. Kavi, K. M. Jude, S. B. Nissen, L. W. Wat, L. Coassolo, M. Zhao, G. Asae Santana-Oikawa, B. B. Broido, K. C. Garcia, K. J. Svensson

The paper uses AlphaFold2 to predict ligand-receptor interactions for single-pass transmembrane receptors with high accuracy.

bioRxiv · Mar 16, 2023Biochemistry

Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for co-receptor discrimination

N. Tsutsumi, S. Hwang, S. Hansen, D. Waghray, N. Wang, Y. Miao, C. R. Glassman, N. A. Caveney, K. M. Jude, C. Y. Janda, R. Hannoush, K. C. Garcia

The paper determines the structure of a ternary Wnt-Frizzled-LRP6 complex, revealing how co-receptor discrimination occurs through specific domains.

bioRxiv · Oct 21, 2022Biophysics

Structure of the IL-27 quaternary receptor signaling complex

N. A. Caveney, C. R. Glassman, K. M. Jude, N. Tsutsumi, K. C. Garcia

The paper determines the structure of the IL-27 receptor signaling complex using cryo-EM, revealing a unique three-site assembly mechanism distinct from related cytokines.

bioRxiv · Mar 8, 2022Immunology

Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch

V. S. De Paula, K. M. Jude, S. Nerli, C. R. Glassman, K. C. Garcia, N. G. Sgourakis

This study identifies a helical capping switch in IL-2 that modulates its conformational transitions and drug interactions, providing a framework for designing precision therapeutics.

bioRxiv · Oct 28, 2019Biochemistry