Author

C. R. Glassman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

K. C. Garcia· 4 shared K. M. Jude· 3 shared N. A. Caveney· 2 shared N. Tsutsumi· 2 shared A. T. Miller· 1 shared B. F. Frey· 1 shared C. Weaver· 1 shared C. Y. Janda· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersImmunology

K. C. Garcia

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

IL-2-induced Stat3 Signaling is Critical for Effector Treg Cell Programming

E. C. Dean, D. F. DiToro, D. Pham, M. Gao, B. F. Frey, S. N. Harbour, D. A. Figge, A. T. Miller, C. R. Glassman, K. C. Garcia, R. D. Hatton, C. Weaver

This study identifies IL-2-induced Stat3 signaling as essential for programming iTreg cells to differentiate into eTreg cells and achieve IL-10 transcriptional competency.

bioRxiv · Sep 26, 2023 · PreprintImmunology

Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for co-receptor discrimination

N. Tsutsumi, S. Hwang, S. Hansen, D. Waghray, N. Wang, Y. Miao, C. R. Glassman, N. A. Caveney, K. M. Jude, C. Y. Janda, R. Hannoush, K. C. Garcia

The paper determines the structure of a ternary Wnt-Frizzled-LRP6 complex, revealing how co-receptor discrimination occurs through specific domains.

bioRxiv · Oct 21, 2022Biophysics

Structure of the IL-27 quaternary receptor signaling complex

N. A. Caveney, C. R. Glassman, K. M. Jude, N. Tsutsumi, K. C. Garcia

The paper determines the structure of the IL-27 receptor signaling complex using cryo-EM, revealing a unique three-site assembly mechanism distinct from related cytokines.

bioRxiv · Mar 8, 2022Immunology

Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch

V. S. De Paula, K. M. Jude, S. Nerli, C. R. Glassman, K. C. Garcia, N. G. Sgourakis

This study identifies a helical capping switch in IL-2 that modulates its conformational transitions and drug interactions, providing a framework for designing precision therapeutics.

bioRxiv · Oct 28, 2019Biochemistry