Inhibition of the sodium-dependent HCO3 -transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype.
V. Saint-Criq, A. Guequen, A. R. Philp, S. Villanueva, T. Apablaza, I. Fernandez-Moncada, A. Mansilla, L. Delpiano, I. Ruminot, C. Carrasco, M. Gray, C. A. Flores
This study shows that inhibiting SLC4A4, a sodium-dependent bicarbonate cotransporter, in airway epithelial cells causes a CF-like phenotype with mucus accumulation and reduced mucociliary clearance.
bioRxiv · Dec 14, 2021Physiology