Author

A. Guequen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. A. Flores· 4 shared A. R. Philp· 2 shared L. Delpiano· 2 shared M. Gray· 2 shared S. Villanueva· 2 shared T. Apablaza· 2 shared A. A. San Martin· 1 shared A. Galaz· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersPhysiology

C. A. Flores

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Author profile →

4 papers

Recent·Most cited

Airway succinate chemosensing induces CFTR-dependent anion secretion and mucus clearance which is impaired in cystic fibrosis.

T. Apablaza, M. Barros-Poblete, L. Delpiano, S. Villanueva, A. Guequen, B. Tapia-Balladares, I. J. Haq, F. Tribinos, S. Hernandez-Rivas, B. Verdon, M. G. Biggart, Y. Sanchez, C. Ward, B. D. Baxter, D. Restrepo, , C. A. Flores

bioRxiv · Mar 26, 2024 · PreprintPhysiology

Inhibition of the sodium-dependent HCO3 -transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype.

V. Saint-Criq, A. Guequen, A. R. Philp, S. Villanueva, T. Apablaza, I. Fernandez-Moncada, A. Mansilla, L. Delpiano, I. Ruminot, C. Carrasco, M. Gray, C. A. Flores

This study shows that inhibiting SLC4A4, a sodium-dependent bicarbonate cotransporter, in airway epithelial cells causes a CF-like phenotype with mucus accumulation and reduced mucociliary clearance.

bioRxiv · Dec 14, 2021Physiology

Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease.

G. Vega, A. Guequen, A. R. Philp, A. Gianotti, L. Arzola, M. Villalon, O. Zegarra-Moran, L. J. Galietta, M. A. Mall, C. A. Flores

This study shows that inhibiting KCa3.1 improves mucociliary clearance in a mouse model of muco-obstructive lung disease.

bioRxiv · May 6, 2020Physiology

MCT4 is a high affinity transporter capable of exporting lactate in high-lactate environments

Y. Contreras-Baeza, P. Y. Sandoval, R. Alarcon, A. Galaz, F. Cortes-Molina, K. Alegria, F. Baeza-Lehnert, R. Arce-Molina, A. Guequen, C. A. Flores, A. A. San Martin, L. F. Barros

The paper revises the kinetic properties of MCT4, showing it has high lactate affinity and can extrude lactate in high-lactate environments, challenging previous pH probe-based estimates.

bioRxiv · Mar 27, 2019 · PreprintPhysiology