Author

C. A. Flores

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

A. Guequen· 4 shared A. R. Philp· 3 shared A. Mansilla· 2 shared L. Delpiano· 2 shared M. A. Mall· 2 shared M. Gray· 2 shared S. Villanueva· 2 shared T. Apablaza· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersPhysiology

A. Guequen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Airway succinate chemosensing induces CFTR-dependent anion secretion and mucus clearance which is impaired in cystic fibrosis.

T. Apablaza, M. Barros-Poblete, L. Delpiano, S. Villanueva, A. Guequen, B. Tapia-Balladares, I. J. Haq, F. Tribinos, S. Hernandez-Rivas, B. Verdon, M. G. Biggart, Y. Sanchez, C. Ward, B. D. Baxter, D. Restrepo, , C. A. Flores

bioRxiv · Mar 26, 2024 · PreprintPhysiology

Inhibition of the sodium-dependent HCO3 -transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype.

V. Saint-Criq, A. Guequen, A. R. Philp, S. Villanueva, T. Apablaza, I. Fernandez-Moncada, A. Mansilla, L. Delpiano, I. Ruminot, C. Carrasco, M. Gray, C. A. Flores

This study shows that inhibiting SLC4A4, a sodium-dependent bicarbonate cotransporter, in airway epithelial cells causes a CF-like phenotype with mucus accumulation and reduced mucociliary clearance.

bioRxiv · Dec 14, 2021Physiology

Tamoxifen reduces inflammatory infiltration of neutrophils in the airways.

A. Mansilla, J. Soto, C. Henriquez, A. R. Philp, M. A. Mall, J. Sarmiento, C. A. Flores

This study shows tamoxifen reduces neutrophil infiltration in inflamed airways across multiple mouse models without affecting mucociliary clearance.

bioRxiv · Jun 19, 2020 · PreprintPharmacology & Toxicology

Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease.

G. Vega, A. Guequen, A. R. Philp, A. Gianotti, L. Arzola, M. Villalon, O. Zegarra-Moran, L. J. Galietta, M. A. Mall, C. A. Flores

This study shows that inhibiting KCa3.1 improves mucociliary clearance in a mouse model of muco-obstructive lung disease.

bioRxiv · May 6, 2020Physiology

MCT4 is a high affinity transporter capable of exporting lactate in high-lactate environments

Y. Contreras-Baeza, P. Y. Sandoval, R. Alarcon, A. Galaz, F. Cortes-Molina, K. Alegria, F. Baeza-Lehnert, R. Arce-Molina, A. Guequen, C. A. Flores, A. A. San Martin, L. F. Barros

The paper revises the kinetic properties of MCT4, showing it has high lactate affinity and can extrude lactate in high-lactate environments, challenging previous pH probe-based estimates.

bioRxiv · Mar 27, 2019 · PreprintPhysiology