Author

L. Delpiano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Guequen· 2 shared C. A. Flores· 2 shared M. Gray· 2 shared S. Villanueva· 2 shared T. Apablaza· 2 shared A. Mansilla· 1 shared A. R. Philp· 1 shared B. D. Baxter· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersPhysiology

A. Guequen

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Author profile →

3 papers

Recent·Most cited

Airway succinate chemosensing induces CFTR-dependent anion secretion and mucus clearance which is impaired in cystic fibrosis.

T. Apablaza, M. Barros-Poblete, L. Delpiano, S. Villanueva, A. Guequen, B. Tapia-Balladares, I. J. Haq, F. Tribinos, S. Hernandez-Rivas, B. Verdon, M. G. Biggart, Y. Sanchez, C. Ward, B. D. Baxter, D. Restrepo, , C. A. Flores

bioRxiv · Mar 26, 2024 · PreprintPhysiology

Drug repurposing for Cystic Fibrosis: identification of drugs that induce CFTR-independent fluid secretion in nasal organoids

L. W. Rodenburg, L. Delpiano, V. Railean, R. Centeio, M. C. Pinto, S. M. A. Smits, I. S. van der Windt, C. F. J. van Hugten, S. F. B. van Beuningen, R. N. P. Rodenburg, C. K. van der Ent, M. D. Amaral, K. Kunzelmann, M. A. Gray, J. M. Beekman, G. D. Amatngalim

This study identifies 12 FDA-approved drugs that induce CFTR-independent fluid secretion in nasal organoids, offering potential treatment for CF patients unresponsive to CFTR modulators.

bioRxiv · Sep 23, 2022Cell Biology

Inhibition of the sodium-dependent HCO3 -transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype.

V. Saint-Criq, A. Guequen, A. R. Philp, S. Villanueva, T. Apablaza, I. Fernandez-Moncada, A. Mansilla, L. Delpiano, I. Ruminot, C. Carrasco, M. Gray, C. A. Flores

This study shows that inhibiting SLC4A4, a sodium-dependent bicarbonate cotransporter, in airway epithelial cells causes a CF-like phenotype with mucus accumulation and reduced mucociliary clearance.

bioRxiv · Dec 14, 2021Physiology