Selective localization of Mfn2 near PINK1 enable its preferential ubiquitination by Parkin on mitochondria
M. Vranas, Y. Lu, S. Rasool, N. Croteau, J. D. Krett, V. Sauve, K. Gehring, E. A. Fon, T. M. Durcan, J.-F. Trempe
The paper identifies Mfn2 as a preferred Parkin substrate due to its proximity to PINK1, which facilitates Parkin activation and ubiquitination on mitochondria.
bioRxiv · Aug 25, 2021Biochemistry