Author

T. M. Durcan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1

Frequent Co-Authors

E. A. Fon· 4 shared C. X.- Q. Chen· 2 shared G. Maussion· 2 shared J.-F. Trempe· 2 shared N. Croteau· 2 shared A. Khoutorsky· 1 shared A. MacDonald· 1 shared A. U. Guzman· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersCell Biology

E. A. Fon

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome

M. Hooshmandi, V. Sharma, C. T. Perez, R. Sood, K. Simbriger, C. Wong, K. C. Lister, A. U. Guzman, T. D. Bartley, C. Rocha, G. Maussion, E. Nadler, P. M. Roque, I. Gantois, J. Popic, , A. Khoutorsky

The paper shows that suppressing the ISR pathway in excitatory neurons of FXS mice leads to autism-like behaviors and that restoring it rescues these phenotypes.

bioRxiv · Apr 24, 2023 · PreprintNeuroscience

MerTK mediates the immunologically silent uptake of alpha-synuclein fibrils by human microglia

M.-F. Dorion, K. Senkevich, M. Yaqubi, N. W. Kieran, C. X.- Q. Chen, A. MacDonald, W. Luo, A. Wallis, I. Shlaifer, J. Hall, R. W. R. Dudley, I. A. Glass, Birth Defects Research Laboratory, J. A. Straton, E. A. Fon, , L. M. Healy

This study shows MerTK mediates microglial uptake of alpha-synuclein fibrils without triggering inflammation and links MERTK variants to Parkinson's disease.

bioRxiv · Mar 4, 2023 · PreprintCell Biology

Structure-based design and characterization of Parkin activating mutations

J.-F. Trempe, M. U. Stevens, N. Croteau, M. A. Eldeeb, Z. W. Zeng, R. Toth, T. M. Durcan, W. Springer, E. A. Fon, M. M. K. Muqit

The paper identifies three Parkin activating mutations that rescue mitophagy defects in cell-based studies, suggesting therapeutic potential for Parkinson's disease.

bioRxiv · Feb 22, 2022Biochemistry

Selective localization of Mfn2 near PINK1 enable its preferential ubiquitination by Parkin on mitochondria

M. Vranas, Y. Lu, S. Rasool, N. Croteau, J. D. Krett, V. Sauve, K. Gehring, E. A. Fon, T. M. Durcan, J.-F. Trempe

The paper identifies Mfn2 as a preferred Parkin substrate due to its proximity to PINK1, which facilitates Parkin activation and ubiquitination on mitochondria.

bioRxiv · Aug 25, 2021Biochemistry

Standardized quality control workflow to evaluate the reproducibility and differentiation potential of human iPSCs into neurons

C. X.- Q. Chen, N. Abdian, G. Maussion, R. A. Thomas, I. Demirova, E. Cai, M. Tabatabaei, L. K. Beitel, J. Karamchandani, E. A. Fon, T. M. Durcan

The paper establishes a standardized quality control workflow to assess variability and reproducibility of human iPSCs in differentiation into neurons and other germ layers.

bioRxiv · Jan 13, 2021 · PreprintCell Biology