Expression and function of SLC38A5, an amino acid-coupled Na+/H+ exchanger, in triple-negative breast cancer and its relevance to macropinocytosis.
S. Ramachandran, S. Sennoune, M. Sharma, M. Thangaraju, V. Suresh, Y. D. Bhutia, K. Pruitt, V. Ganapathy
This study identifies SLC38A5 as an upregulated amino acid transporter in triple-negative breast cancer that promotes macropinocytosis, expanding its role beyond amino acid transport to support cancer cell nutrition.
bioRxiv · Jun 17, 2021Cancer Biology