S. Chattopadhyay

Calcitriol impairs the secretion of IL-4 and IL-13 in Th2 cells via modulating VDR-Gata3-Gfi1 axis

Single-cell transcriptomic and TCR analysis of human Cytomegalovirus (hCMV)-specific memory T cells reveals effector and pre-effectors of CD8+- and CD4+-cytotoxic T cells

The paper characterizes hCMV-specific memory T cells using single-cell transcriptomics and TCR analysis, identifying distinct functional subsets and their roles in immunity.

Ancestral SARS-CoV-2 driven antibody repertoire diversity in an unvaccinated individual correlates with expanded neutralization breadth

The paper examines antibody diversity in an unvaccinated SARS-CoV-2 infected individual, finding that post-vaccination neutralization breadth against Omicron variants is comparable to vaccinated individuals and breakthrough infections.

A mechanistic insight into Nigella sativa mediated anticancer effect on breast cancer through regulation of various miRNAs: An in vitro & in vivo study

This study investigates the anticancer effects of Nigella sativa volatile oil on breast cancer cells and mice, showing synergistic anti-tumorigenic properties through miRNA regulation and apoptosis induction.

How Efficient is the k-means Clustering to Analyze the CT images of Pyogenic and Amoebic Liver Abscess?

The paper evaluates k-means clustering for segmenting CT images of amoebic and pyogenic liver abscesses, finding better performance for pyogenic abscesses.

Inherent evolutionary unpredictability in cancer model system

This study shows that cancer evolution can be inherently unpredictable, using agent-based models and patient-derived xenograft data to demonstrate chaotic clonal dynamics.

DNA damage response signaling is crucial for effective Chikungunya virus replication

This study shows that Chikungunya virus (CHIKV) infection activates DNA damage response (DDR) pathways, increases DNA damage, and interacts with Chk2 and Chk1 to facilitate viral replication and cell cycle arrest.

A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 delta variant

This paper identifies two potent monoclonal antibodies from an Indian donor that neutralize SARS-CoV-2 variants including Delta, showing protection in a mouse model.

Isolation and Characterization of SARS-CoV-2 strains circulating in Eastern India.

The paper isolates and characterizes five SARS-CoV-2 strains from India, showing variations in cytotoxicity and cell line permissiveness, and finds both Covaxin and Covishield vaccines neutralize all isolates effectively.

Telmisartan restricts Chikungunya virus infection in vitro and in vivo through the AT1/ PPAR-γ/MAPKs pathways

This study shows Telmisartan reduces Chikungunya virus infection in vitro and in vivo by modulating host pathways including AT1/PPAR-γ/MAPKs.

MK2a inhibitor CMPD1 abrogates chikungunya virus infection by modulating actin remodeling pathway

This study shows that MK2 and MK3 inhibition with CMPD1 reduces CHIKV infection by blocking actin remodeling and viral release, with potential for antiviral development.

Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host-factors having implication in the disease pathogenesis and severity

This study uses quantitative proteomics to analyze SARS-CoV-2-infected hamster lung tissues, identifying differentially expressed proteins and pathways linked to disease pathogenesis and severity.

Elevation of TRPV1 expression on T cells during experimental immunosuppression

This study shows TRPV1 expression increases during T cell immunosuppression and contributes to elevated intracellular calcium levels, similar to immune activation.

Docosahexaenoic acid (DHA), a nutritional supplement, modulates steroid insensitivity in asthma

This study shows DHA improves steroid sensitivity in asthma models and is lower in steroid-insensitive asthmatics.

Molecular epidemiology of Japanese Encephalitis Virus in pig population of Odisha, Assam and Manipur states of India

This study investigates JEV prevalence and molecular epidemiology in pigs from three Indian states, finding higher infection rates in Manipur and identifying genotype III as dominant with specific mutations.

Autoimmunity Risk Gene IRGM is a Master Negative Regulator of Interferon Response by Controlling the Activation of cGAS STING and RIG-I-MAVS Signaling Pathways

This study identifies IRGM as a negative regulator of interferon response by controlling cGAS-STING and RIG-I-MAVS pathways, linking its deficiency to autoimmunity and antiviral resistance.

Transient Receptor Potential Ankyrin1 channel is endogenously expressed in T cells and regulates immune functions

This study shows TRPA1 is expressed in T cells and modulates calcium levels and activation markers during T cell stimulation.