V. Mohanty

Transcriptional and phenotypic heterogeneity underpinning venetoclax resistance in AML

This study identifies four transcriptionally distinct venetoclax-resistant clusters in AML, revealing phenotypic, genetic, and drug response differences and their implications for treatment resistance.

Biophysical principles predict fitness of SARS-CoV-2 variants

This paper develops a biophysical model to predict the fitness of SARS-CoV-2 variants based on RBD binding thermodynamics and epistatic interactions.

Maximum Mutational Robustness in Genotype-Phenotype Maps Follows a Self-similar Blancmange-like Curve

The paper proves that maximum mutational robustness in genotype-phenotype maps follows a fractal sums-of-digits function and shows this bound is achieved by RNA secondary structure and HP model phenotypes.

Integrated single-cell functional and molecular profiling of extracellular vesicle secretion in metastatic breast cancer

The paper identifies a four-gene signature associated with EV secretion in breast cancer and links it to poor prognosis and immune evasion.

Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host-factors having implication in the disease pathogenesis and severity

This study uses quantitative proteomics to analyze SARS-CoV-2-infected hamster lung tissues, identifying differentially expressed proteins and pathways linked to disease pathogenesis and severity.

The proteomic landscape of resting and activated CD4+ T cells reveal insights into cell differentiation and function

This study uses proteomic profiling to compare resting and activated human CD4+ T cells, identifying protein changes linked to activation, differentiation, and immune function.

Targeting uncoupling of copy number and gene expression in cancers

The paper analyzes multiomics data to show that uncoupling of copy number and gene expression (UCNE) in cancer is associated with oncogenic signaling and immune suppression, and identifies potential therapeutic targets.

Inhibition of the av integrin-TGF-b axis improves natural killer cell function against glioblastoma stem cells

The paper shows that inhibiting the integrin-TGF-β axis enhances NK cell function against glioblastoma stem cells, suggesting it as a therapeutic target.

CIS checkpoint deletion enhances the fitness of cord blood derived natural killer cells transduced with a chimeric antigen receptor

This paper combines CIS checkpoint deletion with CAR engineering in NK cells to enhance their metabolic fitness and anti-tumor activity in a lymphoma model.