S. Senapati

A Mem-dELISA platform for dual color and ultrasensitive digital detection of colocalized proteins on extracellular vesicles

The paper introduces a Mem-dELISA platform for ultrasensitive, dual-color detection of colocalized proteins on extracellular vesicles, demonstrating its application in cancer research.

Prior exposure to malaria decreases SARS-CoV-2 mediated mortality in K18-hACE2 mice without influencing viral load in lungs

This study shows that prior malaria exposure in K18-hACE2 mice reduces SARS-CoV-2 mortality without affecting lung viral load.

Polymer Model Unveils Quantitative Association of Chromatin Conformation and Gene Regulation

The paper introduces a computational framework linking chromatin structure to gene regulation using polymer models and Hi-C data, showing how CTCF deletion affects gene expression in limb development.

Detection of EGFR and its Activity State in Plasma CD63-EVs from Glioblastoma Patients: Rapid Profiling using an Anion Exchange Membrane Sensor

This paper introduces a novel immunoassay for detecting EGFR and its activity state in plasma CD63-EVs from glioblastoma patients, achieving high sensitivity and specificity for early detection.

Isolation and Characterization of SARS-CoV-2 strains circulating in Eastern India.

The paper isolates and characterizes five SARS-CoV-2 strains from India, showing variations in cytotoxicity and cell line permissiveness, and finds both Covaxin and Covishield vaccines neutralize all isolates effectively.

Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG

This study shows that fetal-derived extracellular matrix hydrogels reduce fibroblast activation in stiffened cardiac tissue by modulating cytoskeletal signaling and CAPG expression.

Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host-factors having implication in the disease pathogenesis and severity

This study uses quantitative proteomics to analyze SARS-CoV-2-infected hamster lung tissues, identifying differentially expressed proteins and pathways linked to disease pathogenesis and severity.

Effect of Variations in the Conserved Residues E371 and S359 on the Structural Dynamics of Protein Z Dependent Protease Inhibitor (ZPI): A Molecular Dynamic Simulation Study

This study uses molecular dynamics simulations to analyze how mutations at conserved residues E371 and S359 affect the structural dynamics of ZPI, revealing their role in RCL flexibility and protease inhibition.

Tissue distribution of ACE2 protein in Syrian golden hamster (Mesocricetus auratus) and its possible implications in SARS CoV-2 related studies

This study examines ACE2 protein distribution in Syrian golden hamsters, finding high expression in kidney, intestine, and brain but not in lung or large intestine, with implications for SARS-CoV-2 research.

Macrophage migration inhibitory factor (MIF) of Syrian golden hamster (Mesocricetus auratus) has similar structure and function as human MIF and promotes pancreatic tumor growth in vivo

This study characterizes the structure and function of Syrian golden hamster MIF, showing similarity to human MIF and demonstrating its role in promoting pancreatic tumor growth in vivo.

SIR proteins create compact heterochromatin fibers

This study reconstitutes SIR heterochromatin fibers in budding yeast and shows they are highly compact, requiring H4K16 and Sir3-Sir4 interactions.