Outflanking Immunodominance to Target Subdominant Broadly Neutralizing Epitopes
D. Angeletti, I. Kosik, W. T. Yewdell, C. M. Boudreau, V. V. Mallajosyula, M. Chambers, M. Prabhakaran, H. D. Hickman, A. B. McDermott, G. Alter, J. Chaudhuri, J. W. Yewdell
This study shows that immunodominance in influenza HA can be overcome by targeting the conserved stem through specific immunization strategies.
bioRxiv · Jun 14, 2018Immunology