H. D. Hickman

B cell-intrinsic STAT3-mediated support of latency and interferon suppression during murine gammaherpesvirus 68 infection revealed through an in vivo competition model

This study shows that B cell-intrinsic STAT3 supports gammaherpesvirus latency and suppresses interferon responses in mice, using a competitive infection model.

Ongoing Production of Tissue-Resident Macrophages from Hematopoietic Stem Cells in Healthy Adult Macaques

This study shows that hematopoietic stem cells continuously replenish tissue-resident macrophages in healthy adult macaques, challenging the notion that all macrophages are derived from yolk sac cells.

IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques

This study examines the roles of IFNγ and IL-10 in SARS-CoV-2 infection of rhesus macaques, finding IL-10 suppresses T cell expansion but promotes tissue-resident memory cell formation.

The ectromelia virus virulence factor C15 facilitates early viral spread by inhibiting NK cell-infected cell contacts

This study identifies C15 as a poxvirus protein that inhibits NK cell cytolytic function, promoting viral spread by blocking NK cell contact with infected cells.

Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues

This study shows that SARS-CoV-2 replication declines in the lungs before T cell responses, while innate immunity restricts viral replication in nasal and oral mucosa in rhesus macaques.

A strategy to suppress STAT1 signalling conserved in pathogenic poxviruses and paramyxoviruses

This study identifies a poxvirus protein that inhibits STAT1 signaling by binding its SH2 domain, revealing a conserved mechanism across poxviruses and paramyxoviruses.

MARCO+ lymphatic endothelial cells sequester arboviruses to limit viremia and viral dissemination

This study identifies MARCO+ lymphatic endothelial cells as key in limiting arboviral viremia by sequestering alphavirus particles in draining lymph nodes and the liver.

Neuraminidase Inhibition Contributes to Influenza A Virus Neutralization by Anti-Hemagglutinin Stem Antibodies

This study shows anti-HA stem antibodies neutralize influenza A virus by inhibiting neuraminidase activity, with implications for therapeutic synergy with NA inhibitors.

Outflanking Immunodominance to Target Subdominant Broadly Neutralizing Epitopes

This study shows that immunodominance in influenza HA can be overcome by targeting the conserved stem through specific immunization strategies.