Beyond the Catalytic Serine: Selective Protease Engagement with Covalent Macrocyclic Activity-based Probes
Marina Barrueco, Ellie Hyde, Ella Sawtell, Jack Mills, Vaia Nikoloudi, Marianne Enget, Maisem Laabei, Markus Lakemeyer, Scott Lovell
This paper introduces covalent macrocyclic activity-based probes (cmABPs) that selectively target non-catalytic residues in serine proteases, demonstrating their effectiveness with plasma kallikrein and urokinase plasminogen activator.
Chemical Science · Jan 1, 2026Peer-reviewedBiochemistry