Scott Lovell

Expanding Macrocyclic Topology through Cysteine-to-N-Terminal Cyclisation Enables Covalent Peptide Inhibitor Discovery

This paper introduces a new cyclisation strategy using a bromomethyl picolinaldehyde linker to expand macrocyclic peptide topologies, leading to more potent and diverse inhibitors.

Beyond the Catalytic Serine: Selective Protease Engagement with Covalent Macrocyclic Activity-based Probes

This paper introduces covalent macrocyclic activity-based probes (cmABPs) that selectively target non-catalytic residues in serine proteases, demonstrating their effectiveness with plasma kallikrein and urokinase plasminogen activator.

Macrocyclic phage display for identification of selective protease substrates

This paper introduces a method using macrocyclic phage display to identify selective protease substrates, demonstrating its effectiveness with FAP and DPP4.

Identification of Covalent Cyclic Peptide Inhibitors Targeting Protein-Protein Interactions Using Phage Display

This paper identifies covalent cyclic peptide inhibitors targeting protein-protein interactions using phage display, demonstrating antiviral activity against SARS-CoV-2.